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About 45 percent of women who’ve tried to lose weight have attempted to do so with the help of dietary supplements, according to an article published in Obesity in , making this a common practice. The evidence for many of these supplements is limited, however, and even when benefits are shown in scientific studies, the increase in weight loss is relatively small. That said, there are several supplements that may be beneficial, but the risks of side effects can be significant, so be sure to check with your doctor to make sure they’d be safe for you before you begin using them. Most dietary supplements for weight loss haven’t been evaluated for safety or effectiveness by the U. Food and Drug Administration. Orlistat is the only over-the-counter diet pill that has been approved by the FDA for weight loss. It’s available in a higher-dosage prescription form or over the counter in a lower dosage under the name Alli. It isn’t recommended for anyone with a body mass index under 27 and comes with some potential side effects.